99% Purity Powder CAS 53-84-9 Brain Health And DNA Repair NAD+ Supplements For Longevity

Product Description:

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in all living cells, essential for numerous biological processes. It serves as a key player in cellular energy metabolism, facilitating the conversion of nutrients into energy through glycolysis, the citric acid cycle, and oxidative phosphorylation. NAD+ is crucial in redox reactions, acting as a carrier of electrons and playing a pivotal role in maintaining cellular redox balance.

Beyond energy production, NAD+ is integral to the regulation of gene expression, particularly through its involvement with sirtuins, a class of proteins involved in stress response, DNA repair, and longevity. Its role extends to DNA repair mechanisms, where enzymes like PARPs utilize NAD+ to repair damaged DNA strands. Overall, NAD+ is indispensable for cellular function, contributing significantly to cellular energy metabolism, redox homeostasis, gene regulation, and DNA repair, thereby supporting overall cellular health and function.

Technical Parameters:

Dosage of NAD+:

The optimal dosage of Nicotinamide Adenine Dinucleotide (NAD+) can vary depending on the specific form of NAD+ used (e.g., NAD+ precursors like NMN or NR, or direct NAD+ supplementation), individual health status, age, and other factors. Here’s a general overview based on current research and recommendations:

1. NAD+ Precursors (e.g., NMN, NR):

NMN (Nicotinamide Mononucleotide): Typical dosages in human studies range from 100 mg to 1000 mg per day. It's often divided into multiple doses throughout the day for better absorption.

NR (Nicotinamide Riboside): Typical dosages vary from 100 mg to 1000 mg per day. Like NMN, NR is often split into multiple doses to enhance absorption and sustain NAD+ levels.

2. NAD+ Supplements (Direct NAD+):

Direct supplementation with NAD+ itself is less common due to challenges in stability and absorption. However, some forms of NAD+ supplements are available in the market.

Dosages for direct NAD+ supplementation are not well-established due to limited research and may vary widely among products.

Function of NAD+:

NAD+ (Nicotinamide Adenine Dinucleotide) serves several essential functions in the body, playing a crucial role in cellular energy production, metabolism, and repair processes. Here’s an overview of its primary functions:

1. Energy Production: NAD+ is central to energy production within cells. It plays a key role in mitochondrial function and is involved in glycolysis, the citric acid cycle (Krebs cycle), and oxidative phosphorylation, all of which are essential processes for generating ATP, the body’s main energy molecule. NAD+ facilitates electron transfer during these reactions, allowing cells to convert nutrients into usable energy efficiently.

2. DNA Repair and Maintenance: NAD+ is critical for DNA repair by activating a family of proteins called PARPs (poly-ADP-ribose polymerases), which repair damaged DNA. Maintaining DNA integrity is essential for preventing mutations and reducing the risk of age-related diseases.

3. Sirtuin Activation and Cellular Aging: NAD+ activates sirtuins, a group of enzymes that influence cellular health, stress response, and longevity. Sirtuins help regulate gene expression, cell survival, and repair mechanisms, potentially reducing the impact of aging and extending cell lifespan.

4. Redox Reactions and Antioxidant Defense: NAD+ is involved in redox reactions, where it alternates between its oxidized form (NAD+) and its reduced form (NADH), playing a significant role in managing oxidative stress. By helping to control oxidation levels, NAD+ supports antioxidant defenses, which are essential for cellular health and reducing the effects of aging.

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