Supply 53-84-9 Beta Nicotinamide Adenine Dinucleotide Pure Powder Beta NAD+

Product Description:

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in all living cells, essential for numerous biological processes. It serves as a key player in cellular energy metabolism, facilitating the conversion of nutrients into energy through glycolysis, the citric acid cycle, and oxidative phosphorylation. NAD+ is crucial in redox reactions, acting as a carrier of electrons and playing a pivotal role in maintaining cellular redox balance.

Beyond energy production, NAD+ is integral to the regulation of gene expression, particularly through its involvement with sirtuins, a class of proteins involved in stress response, DNA repair, and longevity. Its role extends to DNA repair mechanisms, where enzymes like PARPs utilize NAD+ to repair damaged DNA strands. Overall, NAD+ is indispensable for cellular function, contributing significantly to cellular energy metabolism, redox homeostasis, gene regulation, and DNA repair, thereby supporting overall cellular health and function.

Technical Parameters:

Dosage of NAD+:

The optimal dosage of Nicotinamide Adenine Dinucleotide (NAD+) can vary depending on the specific form of NAD+ used (e.g., NAD+ precursors like NMN or NR, or direct NAD+ supplementation), individual health status, age, and other factors. Here’s a general overview based on current research and recommendations:

1. NAD+ Precursors (e.g., NMN, NR):

NMN (Nicotinamide Mononucleotide): Typical dosages in human studies range from 100 mg to 1000 mg per day. It's often divided into multiple doses throughout the day for better absorption.

NR (Nicotinamide Riboside): Typical dosages vary from 100 mg to 1000 mg per day. Like NMN, NR is often split into multiple doses to enhance absorption and sustain NAD+ levels.

2. NAD+ Supplements (Direct NAD+):

Direct supplementation with NAD+ itself is less common due to challenges in stability and absorption. However, some forms of NAD+ supplements are available in the market.

Dosages for direct NAD+ supplementation are not well-established due to limited research and may vary widely among products.

Applications of NAD+:

Nicotinamide Adenine Dinucleotide (NAD+) has several important applications across various fields, including health, research, and therapeutic interventions:

1. Anti-Aging and Longevity: NAD+ has garnered attention for its potential anti-aging effects. Increasing NAD+ levels, either through precursors like NMN (Nicotinamide Mononucleotide) or direct supplementation, is believed to support mitochondrial function, enhance DNA repair mechanisms, and promote overall cellular health. This has led to the development of NAD+ boosting supplements and therapies aimed at potentially extending lifespan and improving health span.

2. Metabolic Health: NAD+ plays a crucial role in cellular metabolism, particularly in the conversion of nutrients into energy. Research suggests that maintaining optimal NAD+ levels could potentially help in managing metabolic disorders such as obesity, diabetes, and metabolic syndrome. Therapeutic approaches targeting NAD+ metabolism are being explored for their potential to mitigate metabolic dysfunction.

3. Neurological Disorders: NAD+ is implicated in neuronal health and function. Studies have shown that NAD+ levels decline in neurodegenerative diseases such as Alzheimer's and Parkinson's. Boosting NAD+ levels through supplementation or activating NAD+-dependent pathways may have therapeutic potential in protecting neurons from degeneration and improving cognitive function.

4. Cardiovascular Health: NAD+ is involved in cardiovascular function, including regulation of vascular tone, endothelial function, and cardiac metabolism. Research indicates that maintaining adequate NAD+ levels could potentially protect against cardiovascular diseases such as hypertension, atherosclerosis, and heart failure. Therapeutic strategies targeting NAD+ pathways are being investigated for their cardiovascular benefits.

5. Cancer Therapy: NAD+ metabolism is closely linked to cellular processes that are dysregulated in cancer cells. Modulating NAD+ levels or targeting NAD+-dependent enzymes involved in DNA repair and cellular survival pathways is being explored as a potential strategy for cancer therapy. Preclinical studies suggest that manipulating NAD+ metabolism could sensitize cancer cells to chemotherapy or radiation therapy.

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