Manufacture Supply Nicotinamide Adenine Dinuclotide NAD+ CAS 53-84-9

Product Description:

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in all living cells, essential for numerous biological processes. It serves as a key player in cellular energy metabolism, facilitating the conversion of nutrients into energy through glycolysis, the citric acid cycle, and oxidative phosphorylation. NAD+ is crucial in redox reactions, acting as a carrier of electrons and playing a pivotal role in maintaining cellular redox balance.

Beyond energy production, NAD+ is integral to the regulation of gene expression, particularly through its involvement with sirtuins, a class of proteins involved in stress response, DNA repair, and longevity. Its role extends to DNA repair mechanisms, where enzymes like PARPs utilize NAD+ to repair damaged DNA strands. Overall, NAD+ is indispensable for cellular function, contributing significantly to cellular energy metabolism, redox homeostasis, gene regulation, and DNA repair, thereby supporting overall cellular health and function.

Technical Parameters:

Dosage of NAD+:

The optimal dosage of Nicotinamide Adenine Dinucleotide (NAD+) can vary depending on the specific form of NAD+ used (e.g., NAD+ precursors like NMN or NR, or direct NAD+ supplementation), individual health status, age, and other factors. Here’s a general overview based on current research and recommendations:

1. NAD+ Precursors (e.g., NMN, NR):

NMN (Nicotinamide Mononucleotide): Typical dosages in human studies range from 100 mg to 1000 mg per day. It's often divided into multiple doses throughout the day for better absorption.

NR (Nicotinamide Riboside): Typical dosages vary from 100 mg to 1000 mg per day. Like NMN, NR is often split into multiple doses to enhance absorption and sustain NAD+ levels.

2. NAD+ Supplements (Direct NAD+):

Direct supplementation with NAD+ itself is less common due to challenges in stability and absorption. However, some forms of NAD+ supplements are available in the market.

Dosages for direct NAD+ supplementation are not well-established due to limited research and may vary widely among products.

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